Dr. Murat Berksoy

Selected food intake and risk of endometriosis
F.Parazzini1,2,4, F.Chiaffarino1, M.Surace1, L.Chatenoud1, S.Cipriani1, V.Chiantera1,
G.Benzi3 and L.Fedele2
1Istituto di Ricerche Farmacologiche ‘Mario Negri’, 20157 Milano, 2Clinica Ostetrico Ginecologica, Universita` di Milano,
20122 Milano and 3Studi di via Fontana, 20122 Milano, Italy
4To whom correspondence should be addressed at: Istituto di Ricerche Farmacologiche ‘Mario Negri’, via Eritrea, 62–20157
Milano, Italy.
BACKGROUND: To offer data on the relationship between diet and risk of pelvic endometriosis, we analysed
data collected in the framework of two case–control studies. METHODS: Data from two case–control studies conducted
in Northern Italy between 1984 and 1999 were combined. Cases were 504 women aged <65 years (median
age 33 years, range 20–65) with a laparoscopically confirmed diagnosis of endometriosis, admitted to a network of
obstetrics and gynaecology departments in Milan, Brescia and Pavia. Controls were 504 women (median age 34
years, range 20–61) admitted for acute non-gynaecological, non-hormonal, non-neoplastic conditions. RESULTS:
Compared to women in the lowest tertile of intake, a significant reduction in risk emerged for higher intake of
green vegetables [odds ratio (OR) 5 0.3 for the highest tertile of intake] and fresh fruit (OR 5 0.6), whereas an
increase in risk was associated with high intake of beef and other red meat (OR 5 2.0) and ham (OR 5 1.8). Consumption
of milk, liver, carrots, cheese, fish and whole-grain foods, as well as coffee and alcohol consumption,
were not significantly related to endometriosis. CONCLUSIONS: This study suggests a link between diet and risk
of endometriosis.

References
Armstrong BK (1979) Diet and hormones in the epidemiology of breast and
endometrial cancers. Nutr Cancer 1,90–95.
Armstrong BK, Brown JB, Clarke HT, Crooke DK, Ha¨hnel R, Masarei JR
and Ratajczak T (1981) Diet and reproductive hormones: a study of vegetarian
and nonvegetarian postmenopausal women. J Natl Cancer Inst 67,
761–767.
Baker RJ and Nelder JA (1978) The GLIM System. In Release. Numerical
Algorithms Group, Oxford.
Bosetti C, Negri E, Franceschi S, Pelucchi C, Talamini R, Montella M, Conti
E and La Vecchia C (2001) Diet and ovarian cancer risk: a case-control
study in Italy. Int J Cancer 93,911–915.
Bosetti C, Altieri A and La Vecchia C (2002) Diet and environmental carcinogenesis
in breast/gynaecological cancers. Cur Opin Obstet Gynecol
14,13–18.
Britton JA, Westhoff C, Howe G and Gammon MD (2000a) Diet and benign
ovarian tumors (United States). Cancer Causes Control 11,389–401.
Britton JA, Westhoff C, Howe GR and Gammon MD (2000b) Lactose and
benign ovarian tumours in a case-control study. Br J Cancer 83,
1552–1555.
Chiaffarino F, Parazzini F, La Vecchia C, Chatenoud L, Di Cintio E and
Marsico S (1999) Diet and uterine myomas. Obstet Gynecol 94,395–398.
Cramer DW, Wilson E, Stillman RJ, Berger MJ, Belisle S, Schiff I,
Albrecht B, Gibson M, Stadel BV and Schoenbaum SC (1986) The
relation of endometriosis to menstrual characteristics, smoking and exercise.
J Am Med Assoc 255,1904–1908.
Darrow SL, Vena JE, Batt RE, Zielezny MA, Michalek AM and Selman S
(1993) Menstrual cycle characteristics and the risk of endometriosis.
Epidemiology 4,135–142.
D’Avanzo B, La Vecchia C, Katsouyanni K, Negri E and Trichopolous D
(1997) An assessment, and reproducibility of food frequency data provided
by hospital controls. Eur J Cancer Prev 6,288–293.
Fentiman IS, Caleffi M, Wang DY, Hampson SJ, Hoare SA, Clark GM,
Moore JW, Bruning P and Bonfrer JM (1988) The binding of blood-borne
estrogens in normal vegetarian and omnivorous women and the risk of
breast cancer. Nutr Cancer 11,101–106.
Franceschi S, Negri E, Salvini S, Decarli A, Ferraroni M, Filiberti R,
Giacosa A, Talamini R, Nanni O and Panarello G (1993) Reproducibility
of an Italian food frequency questionnaire for cancer studies: results for
specific food items. Eur J Cancer 29A,2298–2305.
Goldin BR, Adlercreutz H, Gorbach SL, Warram JH, Dwyer JT, Swenson L
and Woods MN (1982) Estrogen excretion patterns and plasma levels in
vegetarian and omnivorous women. N Engl J Med 307,1542–1547.
Gorbach SL and Goldin BR (1987) Diet and the excretion and enterohepatic
cycling of estrogens. Prev Med 16,525–531.
Grodstein F, Goldman MB and Cramer DW (1994) Infertility in women and
moderate alcohol use. Am. J Publ Health 84,1429–1434.
Houston DE (1984) Evidence for the risk of pelvic endometriosis by age,
race and socioeconomic status. Epidemiol Rev 6,167–191.
Ingram DM, Bennett FC, Willcox D and de Klerk N (1987) Effect of low-fat
diet on female sex hormone levels. J Natl Cancer Inst 79,1225–1229.
Kushi LH, Mink PJ, Folsom AR, Anderson KE, Zheng W, Lazovich D and
Sellers TA (1999) Prospective study of diet and ovarian cancer. Am J Epidemiol
149,21–31.
La Vecchia C, Decarli A, Franceschi S, Gentile A, Negri E and Parazzini F
(1987) Dietary factors and the risk of breast cancer. Nutr Cancer 10,
205–214.
Levi F, Franceschi S, Negri E and La Vecchia C (1993) Dietary factors and
the risk of endometrial cancer. Cancer 71,3575–3581.
Mangtani P and Booth M (1933) Epidemiology of endometriosis. J Epidemiol
Commun Health 47,84–88.
Missmer SA and Cramer DW (2003) The epidemiology of endometriosis.
Obstet Gynecol Clin N Am 30,1–19.
Mori M, Harabuchi I, Miyake H, Casagrande JT, Henderson BE and Ross RK
(1988) Reproductive, genetic, and dietary risk factors for ovarian cancer.
Am J Epidemiol 128,771–777.
Olive DL and Schwartz LB (1993) Endometriosis. New Engl J Med 328,
1759–1769.
Parazzini F, La Vecchia C, Franceschi S, Negri E and Cecchetti G (1989)
Risk factors for endometrioid, mucinous and serous benign ovarian cysts.
Int J Epidemiol 18,108–112.
Parazzini F, Negri E, La Vecchia C, Restelli C and Franceschi S (1992)
Family history of reproductive cancers and ovarian cancr risk: an Italian
case-control study. Am J Epidemiol 135,35–40.
Parazzini F, Ferraroni M, Fedele L, Bocciolone L, Rubessa S and Riccardi A
(1995) Pelvic endometriosis: reproductive and menstrual risk factors at
different stages in Lombardy, northern Italy. J Epidemiol Commun Health
49,61–64.
Perneger TV (1998) What’s wrong with Bonferroni adjustments. Br Med J
316,1236–1238.
Risch HA, Jain M, Marrett LD and Howe GR (1994) Dietary fat intake and
risk of epithelial ovarian cancer. J Natl Cancer Inst 86,1409–1415.
Signorello LB, Harlow BL, Cramer DW, Spiegelman D and Hill JA (1997)
Epidemiologic determinants of endometriosis: a hospital-based casecontrol
study. Ann Epidemiol 7,267–274.
Smith MF (1986) Recent advances in corpus luteum physiology. J Dairy Sci
69,911–926.
Turrini A, Saba A, Perrone D, Cialfa E and D’Amicis A (2001) Food consumption
patterns in Italy: the INN-CA study 1994-1996. Eur J Clin Nutr
55,571–588.
Willett W and Stampfer MJ (1986) Total energy intake: implications for
epidemiologic analyses. Am J Epidemiol 124,17–27.

Düzenli vitamin desteği ile yumurtlamaya bağlı kısırlık riski azalıyor

Use of multivitamins, intake of B vitamins, and risk
of ovulatory infertility
Jorge E. Chavarro, M.D., Sc.D.,a Janet W. Rich-Edwards, Sc.D., M.P.H.,b,c,d
Bernard A. Rosner, Ph.D.,d,e and Walter C. Willett, M.D., Dr.P.H.a,c,d
a Department of Nutrition, c Department of Epidemiology, and e Department of Biostatistics, Harvard School of Public Health,
Boston; b Connors Center for Women’s Health and Gender Biology, and d Channing Laboratory, Department of Medicine,
Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

Objective: To examine whether use of multivitamins and intake of specific nutrients in multivitamins is associated
with ovulatory infertility.
Design: A prospective cohort study.
Setting: The Nurses’ Health Study II.
Patient(s): Eighteen thousand five hundred fifty-five married, premenopausal women without a history of infertility
who attempted a pregnancy or became pregnant between 1991 and 1999.
Intervention(s): None, observational study.
Main Outcome Measure(s): Incident reports of infertility caused by anovulation.
Result(s): During 8 years of follow-up, 438 women reported infertility caused by ovulatory disorder. There was an
inverse association between frequency of multivitamin use and ovulatory infertility. The multivariate-adjusted relative
risk (95% confidence interval) of ovulatory infertility was 0.88 (0.60, 1.28) for women consuming two tablets
per week or less, 0.69 (0.51, 0.95) for women consuming three to five tablets per week, and 0.59 (0.46, 0.75) for
women consuming six or more tablets per week, when compared with women who did not use these supplements
(P, trend <.001). Folic acid appeared to explain part of the association between multivitamin supplement use and
risk of ovulatory infertility.
Conclusion(s): Regular use of multivitamin supplements may decrease the risk of ovulatory infertility. (Fertil
Steril 2008;89:668–76. 2008 by American Society for Reproductive Medicine.)

Sebze meyve gibi antioxidan özellikli gıdaları daha çok tüketen erkeklerde sperm kalitesi daha iyi. Daha az serbest radikallere maruz kalıyorlar

Food intake and its relationship with semen quality:
a case-control study
Jaime Mendiola, Ph.D.,a Alberto M. Torres-Cantero, D.P.H.,b Jose M. Moreno-Grau, Ph.D.,c
Jorge Ten, Ph.D.,a Manuela Roca, M.D.,c Stella Moreno-Grau, Ph.D.,c and Rafael Bernabeu, M.D.a,d
a Department of Reproductive Biology and Medicine, Instituto Bernabeu, Alicante; d Reproductive Medicine Chair, University of
Miguel Hernandez de Elche-Instituto Bernabeu, Alicante; b Division of Preventive Medicine and Public Health, School of
Medicine, University of Murcia, Espinardo (Murcia); and c Department of Environmental and Chemical Engineering,
Technical University of Cartagena, Cartagena, Spain

Objective: To compare dietary habits in normospermic and oligoasthenoteratospermic patients attending a reproductive
assisted clinic.
Design: An observational, analytical case-control study.
Setting: Private fertility clinics.
Patient(s): Thirty men with poor semen quality (cases) and 31 normospermic control couples attending our
fertility clinics.
Intervention(s): We recorded dietary habits and food consumption using a food frequency questionnaire adapted
to meet specific study objectives. Analysis of semen parameters, hormone levels, Y microdeletions, and karyotypes
were also carried out.
Main Outcome Measure(s): Frequency of intake food items were registered in a scale with nine categories ranging
from no consumption to repeated daily consumption.
Result(s): Controls had a higher intake of skimmed milk, shellfish, tomatoes, and lettuce, and cases consumed
more yogurt, meat products, and potatoes. In the logistic regression model cases had lower intake of lettuce and
tomatoes, fruits (apricots and peaches), and significantly higher intake of dairy and meat processed products.
Conclusion(s): Frequent intake of lipophilic foods like meat products or milk may negatively affect semen quality
in humans, whereas some fruits or vegetables may maintain or improve semen quality. (Fertil Steril 2008;

Effect of a statin on an in vitro model of endometriosis
Navid Esfandiari, D.V.M., Ph.D., Mozafar Khazaei, Ph.D., Jafar Ai, Ph.D., Ryszard Bielecki, D.V.M., Lynda Gotlieb, R.N., Edward Ryan, M.B., B.Ch., and Robert F. Casper, M.D. Toronto Centre for Advanced Reproductive Technology; Department of Obstetrics and Gynecology, Division of Reproductive Sciences, Samuel Lunenfeld Research Institute, Mount Sinai Hospital; and University of Toronto, Toronto, Ontario, Canada

Devamı »

Peroxisome proliferator–activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis
Dan I. Lebovic, M.D., M.A.,a Mustafa Kir, M.D.,b and Colleen L. Casey, M.D.a
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, Michigan

Devamı »