Artmış serbest radikaller gebe kalma şansını azaltır

Posted on Apr 19, 2010 in Makaleler | 0 comments

The Impact of Reactive Oxygen Species on Early Human Embryos:
A Systematic Review of the Literature
— Sajal Gupta, Jashoman Banerjee, Ashok Agarwal
Abstract: Oocytes and embryos are constantly exposed to oxidative stress which influences
their developmental competence. But, the antioxidants present in the reproductive tissues
protect the embryos in vivo.
The effects of oxidative stress in Assisted Reproductive Technology (ART) is amplified by lack
of physiological defense by the antioxidants and also due to abundance of potential sources
that can generate Reactive Oxygen Species (ROS) in culture media. Certain levels of ROS are
necessary for sperm function,normal activity in the ovarian follicle, normal sperm-oocyte
interaction and sperm capacitation. But, excessive levels may have adverse effects on sperm
DNA, fertilization and embryo quality.
ROS not only accelerate apoptosis in the cell by direct DNA damage, but also affect the DNA
repair mechanisms along with alterations in important check points in cell cycle. In-vitro
developmental arrests are documented in mammalian embryos that are exposed to oxidative
stress. Hence blastocyst development in vitro lags behind blastocyst development in vivo.
Sperm DNA damage caused by elevated ROS levels results in embryo development arrest and
poor fertility outcomes with ART. This article reviews the literature on the sources of ROS
generation in ART setting and enumerates strategies to overcome oxidative stress.

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